02-P008 Epithelial cells of Drosophila turn super-competitors during tumor progression

multifunctional regulatory nuclear compartment that, besides hosting ribosome biogenesis, regulates cellular growth, cell death, and the cell cycle. The Myc transcription factor stimulates tissue growth, in part by activating the expression of genes required for ribosome biogenesis. By qRT-PCR we show that Myc is necessary and sufficient for transcriptional activation of vito expression. Our results raise the hypothesis that the integration of signalling and nutritional cues that control cell growth in Drosophila requires Vito to regulate nucleolar function and architecture.